TARGETING VIRUSES AND CELLS FOR SELECTIVE INTERNALIZATION BY CELLS

摘要

2092323 9206180 PCTABS00011 Viruses or cells are targeted for selective internalization into a target in vivo. A molecule specific for a receptor on the surface of the target cell is introduced onto the surface of the virus or cell. The modified virus or cell binds the receptor in vivo) and is internalized by the target cell. The method provides vectors for selective delivery of nucleic acids to specific cell types in vivo and a means to alter the tropism of an infectious agent.