COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OR REPLICATION OF VIRUSES

摘要

The invention relates to compositions and methods for inhibiting the growth or replication of microbes, viruses or self-replicating nucleic acids. Antisense oligonucleotides that bind to strategic sites in the microbe, virus of self-replicating nucleic acid genome find particular utility in preventing proliferation and pathogenesis; and in detecting microbe, virus or self-replicating nucleic acid. Therapeutic compositions comprising at least two oligonucleotides and methods using the compositions are effective in inhibiting the growth or replication of homologous and heterologous microbes, viruses or self-replicating nucleic acids.