| 摘要 |
PCT No. PCT/NL87/00002 Sec. 371 Date Oct. 27, 1987 Sec. 102(e) Date Oct. 27, 1987 PCT Filed Jan. 27, 1987 PCT Pub. No. WO87/04719 PCT Pub. Date Aug. 13, 1987.Method for the extraction and insolubilization of a vitamin-K-dependent carboxylase complex from biological material, for instance a bovine liver homogenate, which can be used for the conversion of, for example, precursors of the blood coagulation factors II, VII, X and especially IX prepared via recombinant DNA-technology, the insolubilized carboxylase complex, as well as the prepared biologically active blood coagulation factors to be used in pharmaceutical compositions.
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