| 摘要 |
The invention relates to the compounds of general formula I: <IMAGE> (I) <IMAGE> in which: R1 represents a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkenyl radical containing from 2 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and which can bear a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidazolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms, R2 and R3, which may be identical or different, each represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms, n is equal to 1 or 2, R4 represents a hydrogen atom, a formyl radical or a methyl radical, with the proviso, however, that R4 is never the methyl radical when n is equal to 2, and either R5 and R6 together form a double bond, or R5 represents a hydrogen atom and R6 a hydroxyl radical, in the form of a mixture of diastereoisomers or of pure isomers, their Nb,-oxides and their addition salts with a pharmaceutically acceptable inorganic or organic acid. These compounds are antitumor agents.
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