发明名称 |
PHOTOSENSITIVE CALCIUM CHELATORS |
摘要 |
NEW PHOTOSENSITIVE CALCIUM CHELATORS The present invention discloses a new class of calcium chelating compounds which have a decreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. However unlike EGTA or BAPTA-like compounds, in which the two halves of the chelator are linked by a simple 1,2-ethanediyl moiety, the compounds of the present invention modify the stereochemical conformation of this linkage by adding bulky substituents or incorporating the linkage into a carbocyclic or heterocyclic ring. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical precursor of the related 2-nitrosobenzophenones. |
申请公布号 |
CA1298305(C) |
申请公布日期 |
1992.03.31 |
申请号 |
CA19880565777 |
申请日期 |
1988.05.03 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA (THE) |
发明人 |
TSIEN, ROGER Y.;ADAMS, STEPHEN R. |
分类号 |
G01N31/00;C07C67/00;C07C227/00;C07C229/18;C07C309/04;C07D317/50;C07D317/52;C07D317/54;C07D317/58;C07D317/62;C07D319/18;C07F9/09;C09K3/00;G01N33/84 |
主分类号 |
G01N31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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