Process for the preparation of imidazo[4,5-d]pyridazine- 1H-substituted compounds useful in the treatment of cardiovascular disorders

摘要

The present invention relates to a process for the preparation of compounds of formula I: <IMAGE> in which m is a number selected from one to four inclusive, and in which each of R1 to R11 and R39 is for example hydrogen. These compounds can be prepared for example by reacting a compound of formula 4 <IMAGE> with NH2NH2, optionally followed by reaction with NOH or TFA, and are useful in the treatment of cardiovascular disorders, having particular interest as angiotensin II antagonists.