| 摘要 |
ER28 ENKEPHALINASE INHIBITORS Inhibition of enkephalinase activity in mammals is achieved by the present novel compounds having the formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or R5-?-, wherein R5 is alkyl, aryl, arylalkyl, heteroaryl, or (heteroaryl)alkyl; R2 and R3 are each independently hydrogen, alkyl, (cycloalkyl)alkyl, aryl, arylalkyl, heteroaryl, or (heteroaryl)alkyl; R4 is hydroxy, alkoxy, arylalkoxy, (heteroaryl)alkoxy, (substituted alkyl)oxy, or -NR6R7, wherein R6 and R7 are each independently hydrogen, alkyl, substituted alkyl, aryl, arylalkyl, or (heteroaryl)alkyl; and n is an integer of 1 to 15. |
