PROCESSO DE OBTENCAO DE MUTEINAS DO FACTOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS (G-CSF), DE PRODUCAO DE ADN RECOMBINANTE, DE CELULAS TRANSFORMADAS E DE COMPOSICOES FARMACEUTICAS

摘要

A granulocyte-stimulating factor (G-CSF) or G-CSF variant differs from natural G-CSF in that one or more amino acids in the sequence 50 51 52 53 54 55 56 Leu-Gly-His-Ser-Leu-Gly-Ile at position 50 to 56 of mature G-CSF with 174 amino acids or at position 53 to 59 of mature G-CSF with 177 amino acids and/or at least one of the 4 His residues at position 43, 79, 156 or 170 of mature G-CSF with 174 amino acids or at position 46, 82, 159 or 173 of mature G-CSF with 177 amino acids are mutated. It is suitable for immunotherapy.