发明名称 |
PROCESS FOR THE PRODUCTION OF D1, D, AND 1/1,2,3,4/TETRAHYDRO-IZOKYNOLINE-1-CARBONIC ACID AND ITS URETANE TYPE DERIVATIVES WITH N-PROTECTION GROUP |
摘要 |
<p>The invention relates to new L- and D-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acids and their derivatives containing urethane-type N-protecting groups of the formula: R-O-CO, wherein R represents a linear or branched C1-6 alkyl group; a benzyl group optionally substituted with one or more halogen atoms, nitro, methyl or methoxy groups; a picolyl group or a 9-fluorenylmethyl group, and their salts, furthermore to a process for preparing these compounds and the corresponding racemates, which comprises condensing glyoxylic acid hydrate and 2-phenethylamine with an N-protecting group of the general formula: R'-O-CO, wherein R' represents a linear or branched C1-3 alkyl group; a benzyl group optionally substituted with one or more halogen atoms or nitro groups; a picolyl group or a 9-fluorenylmethyl group in trifluoroacetic acid or in a halogenated hydrocarbon containing trifluoroacetic acid.</p> |
申请公布号 |
HU914020(D0) |
申请公布日期 |
1992.03.30 |
申请号 |
HU19910004020 |
申请日期 |
1991.12.19 |
申请人 |
GYOGYSZERKUTATO INTEZET KOEZOES VALLALAT,HU |
发明人 |
BAJUSZ,SANDOR,HU;MOHAI,LASZLONE,HU;FEHER,ANDRAS,HU;LAVICH,JANOSNE,HU;SZELL,GYOERGYNE,HU;VEGHELYI,BELANE,HU |
分类号 |
C07D217/26 |
主分类号 |
C07D217/26 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|