摘要 |
1. Leukotriene-B4 antagonists of formula I <IMAGE> (I) are described, in which X is a CH2 group or an oxygen atom, Y is C1-C4-alkoxy or -S(O)p-C1-C4-alkyl, p is 0, 1 or 2 Z is a hydrogen atom or the radical A-B-COOH with A being a hydroxymethylene group or a carbonyl group and B being an alkylene group with 1-6 atoms in the chain or a radical the radical <IMAGE> if X is a CH2 group, R1 is the radical OH, -O-(C1-C4) -alkyl, -O-(C3-C6) -cycloalkyl, -O-(C7-C12) -aralkyl or the radical NHR4 with R4 being hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl, C6-C10-aryl or (C7-C12)-aralkyl as well as their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their use as pharmaceutical agents. |