| 摘要 |
<p>NEW MATERIAL:The compound of formula I (R1 and R3 are lower alkyl; R3 is formyl or aldehyde-protecting group) and its salt. EXAMPLE:5,6-Dimethyl-2-[4-[3-(1,3-dioxolan-2-yl)phenoxyl-cis-2-butenyl amino]-4-(1 H)-pyrimidone. USE:A production intermediate for antiulcer agent. PREPARATION:A compound of formula VIII is made to react with a compound of formula IX according to the reaction formula to obtain the compound of formula X, which is subjected to Gabriel reaction to form a compound of formula XIII. The product is made to react with a compound of formula XIV to obtain the objective pyrimidone derivative of e.g. formula I-I. The compound of formula I and its salt can easily be produced on an industrial scale in high yield at a low cost.</p> |
