| 摘要 |
33/RJN16 18220 TITLE OF THE INVENTION NEW PROCESS FOR MAKING 17-BETA ALKANOYL 3-OXO-4-AZA-5-ALPHA-ANDROST-1-ENES Disclosed is a new process for making 17-beta branched alkanoyl-3-oxo-4-aza-5-.alpha.-androst-1-enes, agents for treating benign prostatic hypertrophy (BPH), by reacting methyl 3-oxs-4-aza-5-.alpha.-antrost-l-ene-17-beta carboxylate with isobutylmagnesium bromide in the novel presence of hexamethyldisilazane (HMDS). Use of the EMDS results in higher yield and less by-products as opposed to the standard Grignard reaction in the absence of HMDS.
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