PROCESS FOR THE PRODUCTION OF N-SUBSTITUTED-AMINOMETHYLPHOSPHONIC ACID DIALKYLESTERS AND OF THE CORRESPONDING ACIDS

摘要

A process for the production of N-substituted aminoethylphosphonic acid derivatives represented by the formula (I) is disclosed <IMAGE> (I) wherein R1 is an alkyl having 1-18 carbon atoms or a cycloolkyl having 3-18 carbon atoms and R2 is hydrogen, methyl or ethyl. This process comprises the steps of: reacting N-alkyl and N-cycloalkylhexahydro-s-triazine of formula <IMAGE> with trialkylphosphites of formula P(OR2)3 in the presence of titanium tetrahydrochloride at -20 DEG -10 DEG C. to yield N-substituted aminomethylphosphonic acid dialkylesters, followed by hydrolysis to yield N-substituted aminomethylphosphonic acid.