发明名称 |
IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
摘要 |
Substituted 4,5-diaryl-2-alkoxyimidazoles of structure (I), in which each group Ar is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R<1> is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; Y is oxygen or sulphur; n is 4 to 12; and X is 5-tetrazolyl, SO3H, P(O)(OR)2, P(O)(OH)2, or P(O)(R)(OR) in which R is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders. |
申请公布号 |
WO9204332(A1) |
申请公布日期 |
1992.03.19 |
申请号 |
WO1991GB01544 |
申请日期 |
1991.09.10 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
HICKEY, DEIRDRE, MARY, BERNADETTE;COOPER, DAVID, GWYNN;JAXA-CHAMIEC, ALBERT, ANDRZEJ |
分类号 |
A61K31/415;A61K31/675;A61P7/02;A61P9/08;A61P9/10;A61P29/00;C07D233/70;C07D233/84;C07D403/12;C07D405/04;C07D405/14;C07D409/04;C07D409/14;C07F9/6506 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|