| 摘要 |
An actuator for use in inhalation therapy comprising a nozzle block (14) having an orifice (24) and at least one bleed hole (18), a deagglomeration chamber, and an exit chamber (32), together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally. |
