| 摘要 |
The present invention relates to phenolic thioetheramides of formula (I) wherein R<1> and R<2> are tert-alkyl or phenyl, Alk<1> and Alk<2> are alkylene; X is sulfer or oxygen, m is 0, 1, or 2; and R is a) wherein R<3> and R<4> are hydrogen or alkyl and Alk<3> is alkylene; or b) wherein Y is CH, N, O, or S; R<6> is hydrogen, alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl or a heterocyclic amine; and R<7> is hydrogen or alkyl. The compounds inhibit 5-lipoxygenase and are useful in the treatment of inflammation and allergic conditions. |
