PHARMACEUTICAL COMPOSITIONS OF RECOMBINANT BETA-INTERFERON AND FORMULATION PROCESSES

摘要

Stable pharmaceutical compositions suitable for parenteral administration to animals or humans are prepared comprising a therapeutically effective amount of a recombinant IFN- beta protein dissolved in an inert carrier medium comprising as solubilizer/stabilizer(s) one or more biocompatible non-ionic polymeric detergents or a combination of one or more biocompatible non-ionic polymeric detergents with an additional solubilizing and/or stabilizing agent, such as sodium dodecyl sulfate or glycerol. Said compositions are in liquid form or lyophilized.