Process of preparing captopril

摘要

An optically active amine compound and a method for preparing same are provided which compound has the structure <IMAGE> in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R1 are independently H, lower alkyl or halogen, R2 is H or lower alkyl and R3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediates for preparing antihypertensive agents, such as captopril.