| 摘要 |
<p>NEW MATERIAL:A peptide (salt) of the formula. USE:A diagnostic or remedy for Grave's disease. PREPARATION:For example, a phenylacetoamidomethyl resin (Pam resin) as a solid phase carrier is condensed with an amino acid having a protected alpha-amino group and a protected side chain functional group from the C-terminal of an peptide in the presence of a condensing agent such as carbodiimide according to the amino acid sequence of the peptide by a solid phase synthetic method to form a peptide bond, followed by removing the protecting groups. The processes using the next protected amino acids are repeated to prepare a protected peptide resin. The protected peptide is cleaved from the carrier resin with trifluoroacetic acid, etc., and the protecting groups are removed to prepare the crude peptide, which is purified by high performance chromatography to provide the peptide of the formula.</p> |
