| 摘要 |
The invention is concerned with an pharmaceutical formulation containing a benzoyl urea derivative according to the formula 1 <CHEM> in which: X is an oxygen or a sulfur-atom; R1 is a hydrogen atom, a group (0-A)n, wherein A represents a hydrogen atom, an alkanoyl group having 1 to 6 carbon atoms, a carbamoyl group optionally substituted by alkyl containing 1 to 6 carbon atoms or by phenyl, a benzylcarbonyl group optionally substituted by halogen, a benzoyl group, a benzyl group, an aryloxycarbonyl group optionally substituted by halogen, or an alkoxycarbonyl-alkyl group containing from 1 to 6 carbon atoms, or R1 is an alkylmercapto group, having 1 to 3 carbon atoms or a group -S-A, wherein A has the above given meaning; R2 is a hydrogen or halogen atom, an alkyl group having 1 to 6 carbon atoms optionally substituted by halogen, or R2 is a nitro group; R3 is a hydrogen or halogen atom, a nitro group, a 1 to 6 carbon atoms containing alkyl group optionally substituted by halogen, an alkoxy group containing 1 to 6 carbon atoms optionally substituted by halogen, a cycloalkyl group, containing 5-10 carbon atoms, optionally substituted by alkyl groups having 1-3 carbon atoms, an alkanoyl group containing from 1 to 6 carbon atoms, a benzoyl group, a nitrile group, an amino group optionally substituted by 1 or 2 alkyl groups having 1 to 3 carbon atoms, an alkoxycarbonyl group containing from 1 to 6 carbon atoms, or a piperidinocarbonyl group; R4 is a hydrogen atom, a group (0-A)m or S-A, wherein A has the above given meaning, or an alkylmercapto group wherein the alkyl group contains from 1 to 3 carbon atoms; R5 is a hydrogen atom, or represents from 1 to 3 halogen atoms; n and m are integers, whereas the sum n+m has the value from 1 to 6, together with an ionic surface-active compound. |
