19,11 (BETA)-BRIDGED STEROIDS, THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

New 19,11 beta -bridged steroids of the general formula I <IMAGE> (I) where R1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1-C4-alkyl radical or, together, for a second bond between the carbon atoms 6 and 7, B and R2 together for a methylene or an ethylene group, Z for the radical of a pentagonal or hexagonal ring, which is possibly substituted and possibly unsaturated, V stands for a possibly substituted carbocyclic or heterocyclic aryl radical, the ring A for <IMAGE> a) M and N together meaning a second bond or M a hydrogen atom and N a hydroxy group, X means an oxygen atom, two hydrogen atoms or a hydroxyimino grouping N DIFFERENCE OH, R3 and D, which are the same or different, respectively a hydrogen atom, a nitrile radical or a C1-C4-alkyl radical or, together, a methylene or ethylene group, E a hydrogen atom or a C1-C4-alkyl radical, D and E together meaning a second bond between carbon atoms 1 and 2 or together a methylene group <IMAGE> b) or <IMAGE> c) with R11 in the meaning of a hydrogen atom or a C1-C8-alkyl radical, are described as well as their pharmaceutically tolerated addition salts with acids. The new compounds possess valuable pharmacological properties.