| 摘要 |
PURPOSE:To produce (+)-rhododendrol having high optical purity on an industrial scale without being influenced by weather, seasons, etc., by treating 4-(p- hydroxyphenyl)-2-butanone with yeast. CONSTITUTION:Yeast is cultured in a medium containing glucose, corn steep liquor and peptone, etc., for about 24-48 hours and mixed with about 0.5g/l-50g/l4-(p-hydroxyphenyl)-2-butanone of a starting substance to start reaction. The reaction time varies with an amount of 4-(p-hydroxyphenyl)-2-butanone added and generally requires 1-7 days. Rhododendrol thus formed is recovered by separating the cell from the medium and extracting the medium and the cell with an organic solvent. The extracted solutions are joined, concentrated under reduced pressure, rhododendrol is purified by silica gel column chromatography and recrystallized to give rhododendrol. |
