| 摘要 |
CALCIUM PHOSPHATE BONE SUBSTITUTE MATERIALS Calcium phosphates useful as bone substitute material or for the manufacture of prosthetic devices have been prepared from calcium hydroxyapatite material which has a uniformly permeable microporous structure chacterized by a substantially uniform pore volume in the range from about 10 to about 90% and by a pronounced threedimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material of marine life by reacting said calcium hydroxyapatite material which has a calcium to phosphorus atomic ratio of about 1.66 with a phosphate-contributing or phosphorus-contributing moiety or with a calcium-contributing or calcium oxidecontributing moiety so as to alter the calcium to phosphorus Ca/P atomic ratio to yield a calcium phosphate material retaining the above-described microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material but having a calcium to phosphorus Ca/P atomic ratio less than or greater than 1.6, such as a calcium phosphate material comprising dicalcium phosphate and/or tricalcium phosphate and having a calcium to phosphorus Ca/P atomic ratio in the range 1.0 1.5 when the calcium hydroxyapatite material is reacted with said phosphate-contributing or phosphorus-contributing moiety or a calcium phosphate material having a calcium to phosphorus Ca/P atomic ratio greater than 1.66 up to 2.0 when the calcium hydroxyapatite material is reacted with said calcium-contributing or calcium oxide-contrib-uting moiety and comprising tetracalcium phosphate. |
