| 摘要 |
The invention relates to a process for the enantiomer-selective preparation of gamma -keto- delta -amino acid derivatives of the formula I <IMAGE> I characterized in that a compound of the formula II <IMAGE> II is converted, using a trialkylchlorosilane, into a compound of the formula III <IMAGE> III this compound is then reacted with a diazoacetate of the formula N2CH2COOR4 (R4 NOTEQUAL H) to give a cyclopropane compound of the formula IV <IMAGE> IV and then the compound IV is converted, by ring-opening and removal of the silyl groups, and where appropriate saponification, into the compound of the formula I, R1, R2, R3, R4 and R5 having the meanings indicated in claim 1.
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