| 摘要 |
<p>NEW MATERIAL:A compound of formula I (R<1> is H, methyl; R<2>, R<3> are H, lower alkyl; R<4> is carboxyl, lower alkoxycarbonyl, carbamoyl, carbonyl, etc.,) or a salt or ester thereof. EXAMPLE:(5R, 6S)-2-[(3RS,5S)-5-carbamoyl-2-iminopyrrolidin-3-yl]thio 6-[(1R)-1- hydroxyethyl]-1-carbapen-2-em-3-carboxylic acid. USE:An antibiotic exhibiting an excellent antibiotic activity against gram positive bacteria and gram negative bacteria. PREPARATION:A compound of formula II (R<5> is a carboxyl-protecting group; Z is a releasing group) is reacted with a compound of formula III [R<6> is (protected) carboxyl, etc.,), followed by removing the protecting group to prepare the compound of formula I.</p> |
