| 摘要 |
Compounds of formula (I) wherein R1 represents alpha in which p represents 2 or 3; R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, a group OCOR5 where R5 is hydrogen or R4, or a group NHR6 or NR7R8 where R6, R7 and R8 are independently C1-2 alkyl; and R3 is hydrogen, chloro, fluoro, bromo, cyclopropyl, C1-4 alkyl, C1-3 alkyl substituted by one, two or three halogen atoms, or R3 is a group (CH2)nR9 where R9 is -CN, -OH, -OCH3, -SH, -SCH3, -C=CH or -CH=CH2 and n is 0 or 1, with the proviso that when n is 0, R9 is not -OH or -SH, or, when R2 is OCOR5 or NHR6, R3 may not be hydrogen; methods of preparation and use in medicaments for the treatment and/or prophylaxis of dementia in mammals. |
