METHOD FOR MODIFYING THE CELL, TISSUE OR HOST TROPISM OF A MICROORGANISM; RECOMBINANT MICROORGANISMS OBTAINED IN THIS WAY AND USE THEREOF IN MEDICINE AND VETERINARY MEDICINE

摘要

The invention relates to a microorganism having a modified cell, tissue or host tropism whereby at least one gene of the microorganism, preferably an essential gene, is brought under the control of a nucleotide sequence specific for the cell, the tissue or the host. The specific nucleotide sequence can be a promoter sequence and/or enhancer sequence, which can be inducible. The invention is also directed at the use of such a recombinant microorganism for the provision of protection against the corresponding natural microorganism.