| 摘要 |
The description relates to a process for producing 4-pregnene-3,20-dione and its derivatives of general formula (I) in which: R1 is a hydrogen or fluorine atom or a methyl group; R2 is a hydrogen atom of a hydroxy group; and R3 and R4 together represent a carbon-carbon bond or R3 is a hydrogen atom, a hydroxy group or an alkanoyloxy group with up to 6 carbon atoms; and R4 is a hydrogen atom or a methyl group; whereby a pregnane derivative of general formula (II) in which: R1, R3 and R4 have the significance given above, ..... represents a single or double bond, R5 is a hydrogen atom, a hydroxy group or an alkanoyloxy group with a maximum of 6 carbon atoms, and R6 is a hydrogen atom or an alkanoyl group with a maximum of 6 carbon atoms, is fermented with a bacterial culture of the mycobacterium species, NRRL B-3805. |
