SUBSTITUTED DERIVATIVES OF 20,21-DINOREBURNAMENINE, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

PCT No. PCT/FR88/00562 Sec. 371 Date Jul. 18, 1989 Sec. 102(e) Date Jul. 18, 1989 PCT Filed Nov. 16, 1988 PCT Pub. No. WO89/04830 PCT Pub. Date Jun. 1, 1989.The invention concerns compounds of formula (I); <IMAGE> (I) <IMAGE> in which R1, R2 and R3, identical or different, stand for hydrogen, halogen, alkyl or alkoxy (C1-5), hydroxy, trifluoromethyl, nitro, amino, alkylamino, dialkylamino, acylamino, R1, R2 and R3 being unable to stand for hydrogen simultaneously and in which (a) stands for (b), (c), or (d), all possible isomeric forms of said products of formula (I) being racemic or optically active, as well as their additional salts with acids, their preparation and the new intermediate products obtained, their application as drugs in particular nootropes, antidepressants, neuronal protectors, anti-anoxics, anti-ischemics, and the compositions containing them.