| 摘要 |
Isosorbide-2-mononitrate of formula (I) is prepd. from isosorbide-2,5-dinitrate of formula (II) by treatment with salts of metals of a low oxidn. state, in an aq. solvent. Pref. metal salts are of Co, Cr, Mn, Pb, Sn, and esp. Cu and Fe. Ferrous sulphate and cuprous chloride are partic. prefd. The prefd. solvent mixt. is between 50/50 and 80/20 ethanol and water, but instead of ethanol, methanol, propanol, acetonitrile, acetic acid, ethylene glycol, dioxan, tetrahydrofuran, etc. may be used. The reaction is effected at any temp. between 0 deg.C and the b.pt. of the mixt., for 2-48 hrs. The ratio of moles of (II) to gram-equivs. of reducing ions is pref. between 1 and 10.
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