| 摘要 |
QA197 7-OXABICYCLO(2.2.1)HEPTANE ANALOGS USEFUL AS INHIBITORS OF 5-LIPOXYGENASE AND CYCLOOXYGENASE A compound of the formula wherein R1 is hydrogen, hydroxy, alkoxy or aryloxy; R2 is hydrogen, hydroxy, alkoxy or aryloxy; or wherein R1 and R2 taken together is an aromatic ring; R3 is hydrogen or lower alkyl; R4 is lower alkyl, substituted alkyl, alkenyl or alkynyl; X is CH2, amino, alkylamino, alkanoylamino, oxygen or a single bond; A is CH2?CH?CH or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; including all stereoisomers thereof. These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes 5-lipoxygenase and cyclooxygenase and as such are useful, for example, as antiinflammatory agents. |
