COLUMN-PACKING MATERIAL FOR GEL-PERMATION CHROMATOGRAPHY, METHOD FOR ITS PREPARATION, AND APPLICATIONS

摘要

A column Packing material to be used in gel permeation chromatography (GPC) consists of support particles with a mean particle diameter of 1 to 50 mu of which the matrix is formed by an inorganic or organic, polymeric and porous hard material with a mean pore diameter of 6 to 50 nm and a pore volume of 0.1 to 3 ml/g, the matrix pores containing chemically bound polymer chains. The column packing material of the invention is characterized in that the polymer chains consist of linear, permeable and not-crosslinked polymers with an upper exclusion limit between 200 and 200,000, the pores of the matrix being entirely filled by the polymer chains. The method of the invention is characterized in that the pores of the support particles are filled by polymer chains chemically bound to the pore surfaces, these polymer chains being permeable to solvents and partly to dissolved substances.