DIPHENYL-METHANE DERIVATIVE AND PHARMACEUTICAL USE

摘要

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula including a diphenylethylene derivative and a benzophenone oxime ether derivative. ( X X ) in which R1 and R2 each are hydrogen hydroxyl or a lower alkoxy U is =CXY or =N-O-W, x is hydrogen cyano or -COR6, R6 being hydroxyl or an amino Y is -R10-COOR3 R3 being hydrogen or a lower alkoxy R10 being an alkylene having 1 to 3 carbon atoms straight or branched -CO-NR4R5, R4 and R5 each being hydrogen a lower alkyl or a lower arylalkyl CH2-NHS02-C6H5 or -C(R8)=NR7, R7 being a lower alkoxy or an aryl R8 is -VR9 V being oxygen sulfur or nitrogen R9 being an alkyl or an aryl, W is -CH2-CO-CH2-COOR13, R13 being hydrogen or a lower alkyl -CH2-C(=NOR14)-CH2-COOR15, R15 being hydrogen or a lower alkyl, R16 being a lower alkyl -CH(CN)-(CH2)q-COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or -(CH2)p-Z, Z being -SH, -SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.