发明名称 |
HLA-DR ANTIGEN GENE AND ITS NUCLEOTIDE SEQUENCE AND ITS USE |
摘要 |
<p>We have found a novel subtype DRw14c and sequenced the nucleotide sequence thereof. DRw14 associated genes can be genetically typed at the DNA level using DRB1-14c sequence specific oligonucleotide probes such as F142 and F144 of the invention. The present invention overcomes the disadvantages of serological typing and provides a reagent that determines a type of a HLA-DR antigen. More specifically, the invention provides an oligonucleotide probe capable of identifying subtypes of a HLA-DR antigen precisely and a reagent containing the oligonucleotide probe. Furthermore, the invention provides a method of detecting a novel HLA-DR antigen.</p> |
申请公布号 |
CA2049449(A1) |
申请公布日期 |
1992.02.21 |
申请号 |
CA19912049449 |
申请日期 |
1991.08.19 |
申请人 |
MITSUI PETROCHEMICAL INDUSTRIES, LTD.;KITASATO INSTITUTE (THE) |
发明人 |
OBATA, FUMIYA;KASHIWAGI, NOBORU |
分类号 |
C12N15/09;A61K38/00;C07K14/74;C12N1/21;C12N15/12;C12Q1/68;G01N33/53;G01N33/566 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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