1,7-SUBSTITUIERTE HEPTIN-2-ONE.

摘要

1-phenyl-1-hydroxy or fluoro-hept-5-yn-2-ones substituted with a C1 to C7 alkyl, C3 to C6 cycloalkyl, aryl, heteroaryl or heterocycloalkyl group at the 1-position and an amino, a dialkylamino, piperidyl, a pyrrolidyl or a hexahydroazepinyl group at the 7-position are disclosed. The preferred compounds are, 1-cyclohexyl-1-phenyl-1-hydroxy-7-dimethylaminohept-5-yn-2-one, 1-cyclohexyl-1-phenyl-1-hydroxy-7-methylaminohept-5-yn-2-one and 1-cyclohexyl-1-phenyl-1-hydroxy-7-ethylaminohept-5-yn-2-one. The compounds are highly specific M1-AChR antagonists with relatively prolonged duration of activity. They are particularly useful in the treatment of neurogenic bladder disorders.