| 摘要 |
<p>The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5 °C to 45 °C for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemolobin based solution cannot have greater than about 50 % of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15 %. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.</p> |
