发明名称 |
Preparation of a polymer/interleukin-2 conjugate |
摘要 |
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, and increase its circulating in vivo half-life.
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申请公布号 |
US5089261(A) |
申请公布日期 |
1992.02.18 |
申请号 |
US19890415046 |
申请日期 |
1989.09.29 |
申请人 |
CETUS CORPORATION |
发明人 |
NITECKI, DANUTE E.;KATRE, NANDINI;GOODSON, ROBERT J.;ALDWIN, LOIS |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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