| 摘要 |
PCT No. PCT/GB91/01171 Sec. 371 Date Jan. 19, 1993 Sec. 102(e) Date Jan. 19, 1993 PCT Filed Jul. 15, 1991 PCT Pub. No. WO92/01698 PCT Pub. Date Feb. 6, 1992.The present invention provides antiviral compounds of Formula (I), and pharmaceutically acceptable salts thereof: <IMAGE> (I) wherein X is -CH2O or -CH2; R1 is hydroxy or amino; R2 is hydrogen or amino; R3 is hydrogen, hydroxymethyl or acyloxymethyl, wherein the acyl group of said acyloxymethyl is selected from the group consisting of C1-7 alkanoyl and benzoyl optionally substituted in the phenyl ring by one, two or three substituents selected from the group consisting of fluoro, chloro, bromo, C1-4 alkyl and C1-4 alkoxy, wherein the alkyl moiety of said C1-4 alkyl and C1-4alkoxy substituents is selected from the group consisting of methyl, ethyl, n- and iso-propyl, n-, sec-, iso- and tert-butyl, R4 is a group of formula: <IMAGE> wherein R5 and R6 are independent selected from hydrogen, C1-6 alkyl and phenyl optionally substituted by one, two or three substituents selected from the group consisting of fluoro, chloro, bromo, C1-4 alkyl and C1-4 alkoxy, wherein the alkyl moiety of said C1-4 alkyl and C1-4 alkoxy substituents is selected from the group consisting of methyl, ethyl, n- and iso-propyl, n-, sec-, iso- and tert-butyl. |
