PHOSPHOLIPID- OR LIPID-COMBINING GLYCOSAMINOGLYCAN, PRODUCTION THEREOF, AND CANCER METASTASIS INHIBITOR

摘要

A compound comprising a glycosaminoglycan combined with a phospholipid or lipid, which has a pharmacological activity of inhibiting cancer metastasis because it can effective y inhibit the adhesion of cancer cells to hemangioendotheliocytes or extracellular matrices. This compound is produced by cleaving and oxidising the terminal of a glycosaminoglycan to give a derivative thereof, and either reacting the primary amino group of a phospholipid with the aldehyde or lactone group of the derivative or with the carboxyl group present in the glycosaminoglycan chain, or reacting the primary amino group of the glycosaminoglycan derivative with the carboxyl group of a phospholipid or lipid derivative. The product is nontoxic and useful as a cancer metastasis inhibitor.