发明名称 |
Method for preparing intermediates for the synthesis of steroid side chains in optically active form |
摘要 |
This invention provides a novel method for the preparation of optically active arylalykylsulfone derivatives, having a chiral center in the alkyl moiety in either the (R)- or the (S)-configuration. These optically active sulfones find use in the stereospecific synthesis of steroid or vitamin D compounds having chiral center at either carbon 24 or carbon 25 of the side chain. The method comprises the steps of reacting an optically active sulfinate ester having a chiral center at sulfur with a racemic alkyl Grignard reagent to obtain a mixture of diastereomeric sulfoxides, separating the mixture of diastereomeric sulfoxides, and oxidizing separately each of the diastereomers to obtain the desired optically active sulfone.
|
申请公布号 |
US5089647(A) |
申请公布日期 |
1992.02.18 |
申请号 |
US19900507971 |
申请日期 |
1990.04.11 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;PERLMAN, KATO L. |
分类号 |
C07J9/00;C07C315/02;C07C317/14 |
主分类号 |
C07J9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|