[(PHENYL-SULPHAMOYL OR SULPHONAMIDO)- 1,2,3,4-TETRAHYDROISOQUINOLINE-2-YL] ALKYL ACID

摘要

11932/11946 The invention provides compounds of the formula (I): (I) and salts thereof; wherein A is a group NR3SO2 or SO2NR3: B is an acyclic hydrocarbon group having from one to six linear carbon atoms, provided that the carbon atom attached to the nitrogen atom is saturated: Y is CO2H or a group hydrolysable to CO2H; R1 is phenyl optionally substituted by one or more substituents chosen from the group comprising halogen, C1-4alkyl, C1-6acyl, C1-4alkoxy, nitro and trifluoromethyl; R2 is hydrogen or one or more C1-4alkyl substituents located at the 1, 3 and 4 positions of the isoquinoline ring: and R3 is hydrogen or C1-6alkyl. Also disclosed are pharmaceutical compositions containing the compounds, methods for making them and the use of the compounds as thromboxane A2 antagonists.