INHIBITION OF HERPESVIRIDAE INFECTION BY ANTISENSE OLIGONUCLEOTIDES

摘要

2089476 9203051 PCTABS00010 Antisense oligomers which are complementary to vital regions of a viral genome or mRNA transcripts thereof which exhibit antiviral activity are provided. Methylphosphonate oligomers complementary to particular sequences of herpes simplex virus type 1("HSV-1") messenger RNA have demonstrated antiviral activity. Methods of inhibiting viral replication using these oligomers are provided.