The present invention relates to a substrate being prepared by coupling of a macromolecule with the hydrophobic surface of a compound for mimicking athero/arteriosclerosis or testing athero/arteriosclerotic risk or for investigating anti-athero/arteriosclerotic effects of drug formulations. The invention relates furthermore to a process for preparing such a substrate, a method for mimicking athero/arteriosclerosis as well as to the use of the substrate for the manufacture of a test system for recognizing athero/arteriosclerotic risk or for detecting anti-athero/arteriosclerotic effects of drug formulations.
