发明名称 NITRATE ESTERS OF CORTICOID COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF
摘要 Compounds of the general formula B-X1-NO2 or their esters or salts, where B has structure (1) where there may be substituents in place of the hydrogens H in the CH group or two hydrogens H2 in the CH2 group shown in the general formula; R and R' are equal or different one from the other and may be hydrogen or linear or branched alkyls having from 1 to 4 carbon atoms, preferably R = R' = CH3; B being a corticosteroid residue; R'' is -(CO-L)t-(X)t1- where t and t1 are integers equal or different one from the other and equal to 0 or 1; where L is a bivalent connecting group; X is equal to X0 where X0 = 0, NH, NR1C where R1C is a linear or branched alkyl having from 1 to 10 C atoms; or equal to X2 where X2 is equal to OH, CH3, Cl, N(-CH2-CH3)2, SCH2F, SH; X1 is a bivalent connecting bridge YO where Y is a C1-C20 alkylene. 00000
申请公布号 WO9815568(A3) 申请公布日期 1998.06.18
申请号 WO1997EP05426 申请日期 1997.10.02
申请人 NICOX S.A.;DEL SOLDATO, PIERO 发明人 DEL SOLDATO, PIERO
分类号 A61K31/57;A61K31/56;A61P19/02;C07J41/00 主分类号 A61K31/57
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