ACTIVATING HYDROXYL GROUPS OF POLYMERIC CARRIERS USING 4-FLUOROBENZENESULFONYL CHLORIDE

摘要

2075719 9203544 PCTABS00011 The invention relates to a method of binding biologically active organic ligands to hydroxyl groups of polymeric carriers. The method involves bringing 4-fluorobenzenesulfonyl chloride into reactive contact with the hydroxyl groups of polymeric carriers in such a manner to form sulfonate groups in place of the hydroxyl groups. The ligand is then brought into reactive contact with the hydroxyl groups of polymeric carrier to replace the sulfonate groups reacted with the organic ligand.