| 摘要 |
PURPOSE:To produce alpha-hydroxy-4-methylthiobutyramide industrially and advantageously under a mild condition of normal temperature and normal pressure by using a bacterium having hydrating activity of alpha-hydroxy-4- methylthiobutronitrile. CONSTITUTION:alpha-Hydroxy-4-methylthiobutyronitrile is converted into alpha- hydroxy-4-methylthiobutyramide by hydrating reaction by action of bacterium to produce alpha-hydroxy-4-methylthiobutyramide. A bacterium belonging to the genus Rhodococcus, Corynebacterium, Pseudomonas, Arthrobacter of Alcaligenes, capable of hydrating alpha-hydroxy-4-methylthiobutronitrile, is used as the bacterium. The reaction condition is 0.01-50 wt.% amount of the cells used and 0.1-70 wt.% alpha-hydroxy-4-methylthiobutronitrile concentration wherein a substrate may be not completely dissolved in the reaction medium. The reaction is carried out at 5-60 deg.C at pH 4-11 for 0.5-100 hours. |
