| 摘要 |
NEW MATERIAL:A 4-aminophenol derivative expressed by formula I (R<1> and R<2> are lower alkyl, lower alkanoyl or cycloalkyl; R<3> is H or lower alkyl; R<4> is naphthyl, naphthyloxy or heterocyclic group which may be substituted with lower alkyl or diphenyl-lower alkyl; Y is single direct bond, lower alkylene or lower alkenylene) or salts thereof. EXAMPLE:4-(2-Furoyl)amino-2,6-dimethylphenol. USE:A 5-lipoxygenase inhibitor having much better antiallergic and anti- inflammatory action than those of well-known inhibitors. PREPARATION:An aniline compound expressed by formula II (ZO is OH which may be protected) or a salt thereof and a carboxylic acid compound expressed by formula III, a salt or a reactive derivative thereof are subjected to condensing reaction and the OH-protecting group, as necessary, is removed to afford the objective compound expressed by formula I. |
