发明名称 |
Process for synthesis of FK-506 intermediates |
摘要 |
A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C10-C18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.
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申请公布号 |
US5087703(A) |
申请公布日期 |
1992.02.11 |
申请号 |
US19900508153 |
申请日期 |
1990.04.11 |
申请人 |
MERCK & CO., INC. |
发明人 |
VOLANTE, RALPH P.;ASKIN, DAVID;SHINKAI, ICHIRO;RYAN, KENNETH M. |
分类号 |
C07D207/08;C07D307/33 |
主分类号 |
C07D207/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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