TESTING FOR METAL IONS

摘要

A method of testing for metal ions uses an antibody which binds both an antigen and the metal ions, the antibody affinity being reduced in the presence of the metal ions. Detection of antigen binding is preferably by means of surface plasmon resonance spectroscopy. Preparation of a suitable antibody, by modifying the complementarity determining regions of the anti-lysozyme antibody HyHEL-5, is described.