ACETAMIDE DERIVATIVES The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
申请公布号
CA2048325(A1)
申请公布日期
1992.02.03
申请号
CA19912048325
申请日期
1991.08.01
申请人
IMPERIAL CHEMICAL INDUSTRIES PLC
发明人
BRITTAIN, DAVID R.;BROWN, STEVEN P.;COOPER, ANTHONY L.;LONGRIDGE, JETHRO L.;MORRIS, JEFFREY J.;PRESTON, JOHN;SLATER, LINDA